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Covance Drug Development Services
Preclinical Services
Covance Drug Development’s preclinical services include toxicology services, pharmaceutical chemistry, nutritional
chemistry and related services. The preclinical area has been a source of innovation by introducing new technologies for client
access to data such as StudyTracker®, electronic animal identification, multimedia study reports and animal and test tube measures
of induced cell proliferation or reproduction. StudyTracker® is an client access product that allows clients of
toxicology, bioanalytical, metabolism and reproductive and developmental toxicology services to review study data and schedules
on a near basis. Covance has preclinical laboratories in locations that include Madison, Wisconsin, Greenfield, Indiana,
Chantilly, Virginia, Battle Creek, Michigan and Indianapolis, Indiana in the United States; Harrogate and Alnwick in the United
Kingdom; Muenster, Germany; Shanghai, China; Porcheville, France; and Singapore.
Toxicology. Covance Drug Development’s preclinical toxicology services include in vivo toxicology studies, which are studies
of the effects of drugs in animals; genetic toxicology studies, which include studies of the effects of drugs on chromosomes,
as well as on genetically modified mice; and other specialized toxicology services. For example, Covance provides
immunotoxicology services in which it assesses the impact of drugs or chemicals on the structure and function of the immune
system and reproductive toxicology services which help its clients assess the risk that a potential new medicine may cause
birth defects.
Pharmaceutical Chemistry. In Covance Drug Development’s pharmaceutical chemistry services, it determines the metabolic
profile and bioavailability of drug candidates.
Nutritional Chemistry and Food Safety. In Covance Drug Development’s nutritional chemistry services, it offers a broad
range of services to the food, nutriceutical and animal feed industries, including nutritional analysis and equivalency, nutritional
content fact labels, microbiological and chemical contaminant safety analysis, pesticide screening and stability testing.
Research Products. Covance Drug Development provides animals for biomedical research. The
research animals it provides are purchased by pharmaceutical and biotechnology companies, university research centers and
contract research organizations as part of required preclinical animal safety and efficacy testing. Through a variety of processes,
technology and specifically constructed facilities, Covance Drug Development provides and
specific pathogen free animals that meet its clients’ rigorous quality control requirements. Covance Drug Development also
has a dedicated animal biosafety level 2 containment vivarium to allow it to provide full service vaccine testing.
Lead Optimization and Translational Services. Covance Drug Development provides lead optimization and translational
services including custom immunology and polyclonal and monoclonal antibody services, metabolism studies and
pharmacokinetic screening as well as toxicology, in vivo pharmacology, imaging services and biomarker services.
Covance Drug Development provides GLP and biomarker services, offers bioimaging capabilities and cardiac
related biomarkers for animals and humans, and has created a Biomarker Center of Excellence dedicated to the development,
validation and testing of biomarkers.
Bioanalytical Services. Covance Drug Development’s bioanalytical testing services, which are conducted in its bioanalytical
laboratory in Indianapolis, Indiana and in its immunoanalytical facility in Chantilly, Virginia, as well as in its laboratories in
Madison, Wisconsin, Harrogate, United Kingdom and Shanghai, China, help determine the appropriate dose and frequency
of drug application from late discovery evaluation through Phase III clinical testing on a globally integrated basis.
Clinical Pharmacology Services
Covance Drug Development provides clinical pharmacology services, including trials, and early patient proof
of concept studies of new pharmaceuticals at its four clinics located throughout the United States and its clinic in Leeds, United
Kingdom.
Central Laboratory Services
Through four central laboratories, one in each of the United States, Switzerland, Singapore, and China, Covance Drug
Development provides central laboratory services to biotechnology and pharmaceutical customers. Covance Drug Development
also has an alliance for central laboratory services testing in Japan with BML, Inc., a leading Japanese laboratory testing company.